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Erythromycin dose uk aku (1 mg) were given in the first period (Figure). Open in a separate window Discussion The effect of different antibiotic treatments was assessed using the following parameters of efficacy: mortality, antibiotic requirements, resistance genes/proteins, bacterial load, and adverse events. Although bactericidal bacteriostatic efficacy in the previous study noncytotoxic subjects has remained good, the antibiotic treatments produced a lower bactericidal and cytotoxic efficacy than i.d. (i.p.) administration. It was believed that the reason why cytotoxicity and bactericidal efficacy were still high is mainly because of the high efficiency i.d. i.p. protocol , , but our studies showed that this is the case. Amoxicillin for cheap differences in antibiotic treatments were observed several parameters, which may have contributed to the difference observed between two groups. This may be because the different types of antibiotics they used have high variability related to the drug concentration and type of antibiotic used , , . Furthermore, the different antibiotic dosing procedures used at different times in this study may have influenced the outcome. An experimental study demonstrated a decrease in bacterial cell viability induced by i.d. antibiotic treatment was similar in all treatments, indicating that the i.d. study is an accurate system to show bactericidal and bacteriostatic efficacy . However, our study only had five treatment periods whereas in the experimental study, number of treatment periods was 13, although the results were still similar . Another difference between the i.d. and a.n. dosing protocols is that in the experimental study, a.n. dosing is done every second day whereas in our study, patients were not given a.n. dosing and antibiotics were given every fourth day. Therefore, a.n. dosing used in epidemiological studies should be observed to determine which antibiotic is more effective. Furthermore, there was no difference between the duration of treatment periods. Therefore, we conclude that the i.d. protocol was a good system to study bactericidal and bacteriostatic efficacy in this study. The higher bacteriostatic efficacy of ceftriaxone than other antibiotics may have been due to the concentration required be same as before i.d. treatment. The lack of effect other combinations antibiotics has been mentioned before , , , . When the use of these other combinations was considered, the combination of ciprofloxacin with aminoglycosides was the most effective among combined antibiotic treatments, but there was no effect on the proportion of patients surviving. These results are consistent with the previous results from same cohort study in Japanese children . However, ciprofloxacin or aminoglycosides combination was more effective than each individual antibiotic, which suggests that the specific antibiotic combination may play a role in effecting the efficacy. addition, our results show that no differences exist in bacteriology, which is not related to the antibiotic used and may be related to different conditions of the host as some bacterial strains were not inhibited. It was suggested by De Vries in this regard that the low resistance of bacteriophages were responsible for the erythromycin buy uk low susceptibility of bacteria to the combination antibiotics . On other hand, some antimicrobial drugs were more effective than others. This is one finding that has yet to be investigated. A previous study also demonstrated no difference in antibiotic resistance genes between a.n. dosing and i.d. treatment protocols . In addition, the different antibiotic dosing processes allowed study the impact of different variables on bactericidal and bacteriostatic efficiency of different antibiotics . However, our study differs from previous studies because our study used the same antibiotic (i.d.) as i.p. protocol, well the length of antibiotic dosing periods (every fourth day) compared to other studies that used a different protocol (i.d. and/or every third day) , , , . The differences in dosage, dosing intervals and drug types may also account for the differences in outcome. Thus, we believe that the results of our study are important for the of microorganisms on respiratory pathway that require antibiotic treatment. Conclusions The bactericidal and bacteriostatic effects of 10 types antibiotics were evaluated in three clinical studies. These methods were compared with i.d. administration of 10 different antibiotics to evaluate the effects of different combinations antibiotics. Our results showed that i.d. treatment with amoxicillin, clindamycin, cefazolin, minocycline, and metronidazole inhibited both susceptibility to and survival of the strains. These differences were observed in different bacteriophage isolates from environmental conditions, suggesting that multiple factors may determine the effectiveness of.
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